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Second coronavirus vaccine is 94.5% effective, buoying hopes of ending pandemic

by Jon lee Anderson
November 16, 2020
in Tech
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A second vaccine has been proven strongly effective against COVID-19, offering more assurance that the global pandemic eventually can be contained.

On Monday, the company Moderna announced that its vaccine reduced the risk of infection by 94.5% — a success rate that exceeds last week’s startling news from Pfizer that its vaccine is 90% effective. Moderna’s candidate also was extremely effective at staving off severe cases of the virus.

The results exceeded medical experts’ expectations and buoyed hopes as the country contends with unprecedented outbreaks and an alarming rise in hospitalizations. But scientists stress additional study is needed to confirm that the vaccines are safe and long-lasting.

Both companies are expected to quickly ask the FDA for permission to distribute their products, raising hopes that the U.S. could have two coronavirus vaccines available by year’s end. Dr. Anthony Fauci, the nation’s top disease expert, told CNN that he expects inoculations to begin “towards the latter part of December.”

While initial supplies will be very limited, many more doses will be ready next year.

“ ‘Normal’ by late ’21 is possible,” said UCSF professor of medicine Dr. Robert M. Wachter on Twitter, predicting a return to life as we once knew it.

Significantly, the Moderna vaccine does not demand the ultra-cold storage needed by the Pfizer vaccine, so it is more practical for pharmacies, health departments and rural hospitals. The Pfizer vaccine must be stored at minus-94 degrees Fahrenheit; the Moderna vaccine needs minus-4 degrees Fahrenheit.

“It is much more doable,” said Dr. Jeffrey Silvers, medical director of Infectious Disease for Sutter Health, at last week’s meeting of the Bay Area Council.

In a bit of a silver lining, the recent surge of cases, while catastrophic for families and communities, has helped accelerate vaccine trials, Stéphane Bancel, chief executive of Moderna, told the Washington Post. That’s because more volunteers are exposed, so data accumulates more quickly.

A previous projection showed that the trial might end sometime early next year, but with so many study participants who are receiving placebos getting infected, it is instead expected to wrap up in seven to 10 days, Bancel said.

The Boston-based biotech company Moderna was informed of the results on a call Sunday afternoon with members of the Data Safety and Monitoring Board, an independent panel analyzing Moderna’s clinical trial data.

There were 95 infections among the 15,000 patients who received an inactive placebo — compared to only five infections in 15,000 patients who were infected after receiving the vaccine, called mRNA-1273, according to the company’s news release.

“It’s just as good as it gets — 94.5% is truly outstanding,” said Fauci.

Of the 11 severe cases of illness, all were reported in people who received the placebo, not the vaccine. This suggests that the vaccine could prevent the worst cases of illness.

“In this pandemic, what has been awful from a public health standpoint, an economic standpoint, is the worry people have to get so sick they have to go to the hospital — so sick they have to get to the ICU and have a high risk of dying,” Bancel said.

If a vaccine could protect 95 percent of people, “that would be a game-changer: the impact on hospitals, the impact on people’s psyche and the impact on deaths,” he said.

Also notably, the Moderna vaccine was tested in people who are at highest risk of disease. The company said that 42% of study participants were older adults and people with chronic illnesses such as cardiac disease and diabetes. It also includes people of color, with African Americans and Hispanics representing 10% and 20% of participants, respectively.

The effort could ease fears of “vaccine hesitancy” among the diverse American population, which would slow an inoculation campaign.

But a full understanding of the vaccines’ safety and efficacy will take more time to reveal itself. Because the FDA’s “emergency use authorization” looks only at short-term data, it doesn’t capture more subtle downstream issues.

Several other vaccines — from AstraZeneca, Johnson & Johnson and Merck — are expected to release data next year. They don’t require ultra-cold storage, so they’ll be easier to administer. And they’ll significantly boost supplies.

Both the Moderna and Pfizer vaccines use the power of genetics to produce their vaccines, enlisting a “messenger RNA,” or mRNA, technology. This is a much faster approach than traditional vaccine development.

Moderna hopes that it will have 20 million doses by the end of this year or early next year. Then it will scale up to 500 million to a billion doses. Pfizer is expecting about 50 million doses to be available by the end of the year, and up to 1.3 billion doses by the end of next year.

Frontline health workers should be the first group to be offered a vaccine, according to the National Academy of Medicine. Next in line would be older adults living in nursing homes and people with significant illnesses that put them at high risk of illness or death.

Next in line would be these groups: “essential workers” in occupations with high risk of exposure to the virus; teachers and school staff, especially in elementary schools; people with illnesses that put them at moderate risk of illness or death; all older adults; people in homeless shelters or group homes and incarcerated people and staff.


CNN and The Washington Post contributed to this article.

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